Paul B McCray Selected Research

Infections

1/2024	Adaptation of SARS-CoV-2 to ACE2H353K mice reveals new spike residues that drive mouse infection.
11/2023	Avian influenza A viruses exhibit plasticity in sialylglycoconjugate receptor usage in human lung cells.
9/2023	IL-13 induced inflammation increases DPP4 abundance but does not enhance MERS-CoV replication in airway epithelia.
1/2023	SARS-CoV-2-Mediated Lung Edema and Replication Are Diminished by Cystic Fibrosis Transmembrane Conductance Regulator Modulators.
1/2022	Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19.
7/2021	Protection of K18-hACE2 mice and ferrets against SARS-CoV-2 challenge by a single-dose mucosal immunization with a parainfluenza virus 5-based COVID-19 vaccine.
4/2021	Eicosanoid signaling as a therapeutic target in middle-aged mice with severe COVID-19.
1/2021	The first few days of a SARS-CoV-2 infection viewed at single-cell resolution.
1/2021	Middle East Respiratory Syndrome Coronavirus Gene 5 Modulates Pathogenesis in Mice.
1/2021	The TMPRSS2 Inhibitor Nafamostat Reduces SARS-CoV-2 Pulmonary Infection in Mouse Models of COVID-19.

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Paul B McCray Research Topics

Disease

35	Infections 01/2024 - 07/2003
34	Cystic Fibrosis (Mucoviscidosis) 01/2022 - 07/2003
12	COVID-19 01/2024 - 01/2020
11	Lung Diseases (Lung Disease) 01/2021 - 07/2003
7	Inflammation (Inflammations) 09/2023 - 11/2003
6	Pneumonia (Pneumonitis) 01/2019 - 06/2008
4	Virus Diseases (Viral Diseases) 07/2021 - 04/2014
4	Vesicular Stomatitis 05/2016 - 10/2005
3	Weight Loss (Weight Reduction) 01/2021 - 01/2020
3	Hemophilia A (Haemophilia) 01/2014 - 09/2005
3	Bacterial Infections (Bacterial Infection) 05/2013 - 07/2003
2	Disease Progression 07/2021 - 03/2015
2	Inborn Genetic Diseases (Disease, Hereditary) 01/2021 - 10/2019
2	Persistent Infection 01/2018 - 09/2012
2	Meconium Ileus 06/2013 - 09/2008
2	Sepsis (Septicemia) 12/2006 - 02/2005
1	Metaplasia 09/2023
1	Edema (Dropsy) 01/2023
1	Paramyxoviridae Infections (Parainfluenza) 07/2021
1	Pulmonary Atelectasis 01/2021
1	Surfactant Dysfunction 01/2021
1	Interstitial Lung Diseases (Interstitial Lung Disease) 01/2021
1	Protein Deficiency 01/2020
1	Fibrosis (Cirrhosis) 12/2016
1	B-Cell Lymphoma (Lymphoma, B Cell) 04/2016
1	Coronavirus Infections 01/2016

Drug/Important Bio-Agent (IBA)

21	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA 01/2023 - 10/2005
17	Proteins (Proteins, Gene)FDA Link 09/2023 - 10/2005
9	VaccinesIBA 07/2021 - 04/2014
7	Messenger RNA (mRNA)IBA 01/2023 - 05/2004
7	Antiviral Agents (Antivirals)IBA 01/2021 - 01/2007
6	Angiotensin-Converting Enzyme 2IBA 01/2024 - 01/2007
4	Dipeptidyl Peptidase 4 (Dipeptidyl Peptidase IV)IBA 09/2023 - 04/2014
4	Peptide Hydrolases (Proteases)FDA Link 01/2021 - 05/2014
4	Surface-Active Agents (Surfactants)IBA 01/2021 - 05/2013
4	AnionsIBA 11/2018 - 03/2011
4	Peptides (Polypeptides)IBA 01/2018 - 11/2003
4	Glycoproteins (Glycoprotein)IBA 05/2016 - 10/2005
4	Antimicrobial PeptidesIBA 11/2009 - 11/2003
3	DefensinsIBA 07/2014 - 07/2003
3	Factor VIII (Coagulation Factor VIII)IBA 01/2014 - 09/2005
3	AntibodiesIBA 05/2011 - 09/2005
2	prostaglandin D2 receptorIBA 01/2022 - 04/2021
2	Prostaglandin D2IBA 01/2022 - 04/2021
2	EicosanoidsIBA 01/2022 - 04/2021
2	Phospholipases (Phospholipase)IBA 01/2022 - 04/2021
2	asapiprantIBA 01/2022 - 04/2021
2	ChloridesIBA 10/2021 - 09/2008
2	COVID-19 VaccinesIBA 07/2021 - 04/2021
2	Protein CIBA 01/2021 - 03/2016
2	RNA (Ribonucleic Acid)IBA 10/2020 - 08/2020
2	Monoclonal AntibodiesIBA 01/2020 - 05/2011
2	CytokinesIBA 01/2019 - 01/2007
2	ChemokinesIBA 01/2018 - 01/2007
2	EndotoxinsIBA 01/2018 - 06/2008
2	LactoferrinIBA 04/2016 - 07/2014
2	MucinsIBA 04/2016 - 05/2011
2	Complementary DNA (cDNA)IBA 01/2014 - 06/2013
2	MicroRNAs (MicroRNA)IBA 10/2013 - 04/2011
2	Chloride Channels (Chloride Channel)IBA 01/2007 - 10/2005
2	beta-DefensinsIBA 05/2004 - 03/2004
1	InterleukinsIBA 05/2024
1	SugarsIBA 11/2023
1	GlycoconjugatesIBA 11/2023
1	N-Acetylneuraminic Acid (Sialic Acid)IBA 11/2023
1	Interleukin-13IBA 09/2023
1	Phospholipases A2 (Phospholipase A2)IBA 01/2022
1	Nonsense Codon (Nonsense Mutation)IBA 10/2021
1	SARS-CoV-2 spike proteinIBA 07/2021
1	CVXGA1 COVID-19 vaccineIBA 07/2021
1	InterferonsIBA 01/2021
1	Serine Proteases (Serine Protease)IBA 01/2021
1	camostatIBA 01/2021
1	Codon (Codons)IBA 01/2021
1	avoralstatIBA 01/2021
1	Protease Inhibitors (Protease Inhibitor)IBA 01/2021
1	Pulmonary Surfactants (Pulmonary Surfactant)IBA 01/2021
1	AntipainIBA 01/2021
1	Trypsin InhibitorsIBA 01/2021
1	nafamostatIBA 01/2021
1	Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA 01/2021
1	ATP-Binding Cassette Transporters (ABC Transporters)IBA 01/2021
1	IgA receptor (protein B)IBA 01/2021
1	PCI-27483IBA 01/2021
1	Neutralizing AntibodiesIBA 01/2020
1	Angiotensin IIIBA 01/2018
1	BradykininIBA 01/2018
1	CarboxypeptidasesIBA 01/2018
1	Bradykinin Receptors (Bradykinin Receptor)IBA 01/2018
1	TetraspaninsIBA 07/2017
1	F-Box ProteinsIBA 12/2016
1	UbiquitinIBA 12/2016
1	Proteasome Endopeptidase Complex (Proteasome)IBA 12/2016
1	Ligases (Synthetase)IBA 12/2016
1	Small Interfering RNA (siRNA)IBA 12/2016
1	TubulinIBA 04/2016
1	Peroxidase (Myeloperoxidase)IBA 04/2016
1	CalciumIBA 04/2016
1	Keratin-18 (Keratin 18)IBA 03/2016

Therapy/Procedure

12	Therapeutics 01/2024 - 01/2007